Article
Importance of STAT3 Polymorphisms on the Risk and Clinical Characteristics of Rheumatoid Arthritis.
Iranian journal of allergy, asthma, and immunology - 24 Dec 2022
Salehi Amirhossein, Hazrati Ebrahim, Ranjbar Hamta, Behroozi Javad, Pakzad Bahram, Mousavi Maryam, Mousavi Mojtaba, Hossein Balam Marzieh, Salesi Mansour
Abstract excerpt
Signal transducer and activator of transcription 3 (STAT3) has been introduced as one of the critical genetic factors in the pathogenesis of rheumatoid arthritis (RA). Single nucleotide polymorphisms (SNPs) in microRNA binding sites, known as miRSNPs, are a class of common variants in the 3' untranslated regions of genes targeted by miRNAs. miRSNPs unbalance gene expression by disrupting the binding regions of...
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