Article
STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility.
Genes and immunity - 1 Apr 2010
Cénit M C, Alcina A, Márquez A, Mendoza J L, Díaz-Rubio M, de las Heras V, Izquierdo G, Arroyo R, Fernández O, de la Concha E G, Matesanz F, Urcelay E
Abstract excerpt
STAT3 (signal transducer and activator of transcription 3) signaling is a critical component of Th17-dependent autoimmune processes. Genome-wide association studies (GWAS) have revealed the role of the STAT3 gene in inflammatory bowel disease (IBD) susceptibility, although confirmation in clinical subphenotypes is warranted. Mice with targeted deletion of Stat3 in T cells are resistant to experimental autoimmune...
Topics
- Alleles
- Base Sequence
- Colitis, Ulcerative
- Crohn Disease
- Gene Frequency
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Haplotypes
- Humans
- Inflammatory Bowel Diseases