Article
Race-specific association of an IRGM risk allele with cytokine expression in human subjects.
Scientific reports - 9 Aug 2023
Ajayi Teminioluwa, Rai Prashant, Shi Min, Gabor Kristin A, Karmaus Peer W F, Meacham Julie M, Katen Kevin, Madenspacher Jennifer H, Schurman Shepherd H, Fessler Michael B
Abstract excerpt
Immunity-related GTPase family M (IRGM), located on human chromosome 5q33.1, encodes a protein that promotes autophagy and suppresses the innate immune response. The minor allele of rs13361189 (-4299T>C), a single nucleotide polymorphism in the IRGM promoter, has been associated with several diseases, including Crohn's disease and tuberculosis. Although patterns of linkage disequilibrium and minor allele...
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