Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

doi:10.1016/j.ajhg.2010.01.017

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Article

Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

American journal of human genetics - 12 Feb 2010

Jakkula Eveliina, Leppä Virpi, Sulonen Anna-Maija, Varilo Teppo, Kallio Suvi, Kemppinen Anu, Purcell Shaun, Koivisto Keijo, Tienari Pentti, Sumelahti Marja-Liisa, Elovaara Irina, Pirttilä Tuula, Reunanen Mauri, Aromaa Arpo, Oturai Annette Bang, Søndergaard Helle Bach, Harbo Hanne F, Mero Inger-Lise, Gabriel Stacey B, Mirel Daniel B, Hauser Stephen L, Kappos Ludwig, Polman Chris, De Jager Philip L, Hafler David A, Daly Mark J, Palotie Aarno, Saarela Janna, Peltonen Leena

Abstract excerpt

Genetic risk for multiple sclerosis (MS) is thought to involve both common and rare risk alleles. Recent GWAS and subsequent meta-analysis have established the critical role of the HLA locus and identified new common variants associated to MS. These variants have small odds ratios (ORs) and explain only a fraction of the genetic risk. To expose potentially rare, high-impact alleles, we conducted a GWAS of 68...

Topics

Alleles
Base Pairing
Case-Control Studies
Genetic Predisposition to Disease
Genetics, Population
Genome-Wide Association Study
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Linkage Disequilibrium

Multiple Sclerosis

Polymorphism, Single Nucleotide

Reproducibility of Results

STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 20159113
DOI: 10.1016/j.ajhg.2010.01.017
PMCID: PMC2820168

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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