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LncRNA MEG3 as a biomarker and therapeutic target in rheumatoid arthritis: Insights from gene polymorphisms, expression patterns, and functional mechanisms.

Clinical immunology (Orlando, Fla.) - 1 Dec 2025

Tao Sha-Sha, Wei Hai-Fen, Xu Shu-Zhen, Li Xiao-Xiao, Zhu Yan-Yu, Tang Jian, Li Wen-Jie, Chang Yu-Wan, Chen Zhu, Pan Hai-Feng

Abstract excerpt

Maternally expressed gene 3 (MEG3) is implicated in autoimmunity, but its role in rheumatoid arthritis (RA) is unclear. This study aimed to investigate gene polymorphisms, expression patterns, and functional mechanisms of MEG3 in RA pathogenesis and its clinical associations. MEG3 single nucleotide polymorphisms (SNPs) were genotyped in 551 RA patients and 595 controls, finding no association with RA...

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PMID: 40885371
DOI: 10.1016/j.clim.2025.110590

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