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Article

Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma.

Haematologica - 1 Jun 2016

Yoo Hae Yong, Kim Pora, Kim Won Seog, Lee Seung Ho, Kim Sangok, Kang So Young, Jang Hye Yoon, Lee Jong-Eun, Kim Jaesang, Kim Seok Jin, Ko Young Hyeh, Lee Sanghyuk

Abstract excerpt

CTLA4 and CD28 are co-regulatory receptors with opposite roles in T-cell signaling. By RNA sequencing, we identified a fusion between the two genes from partial gene duplication in a case of angioimmunoblastic T-cell lymphoma. The fusion gene, which codes for the extracellular domain of CTLA4 and the cytoplasmic region of CD28, is likely capable of transforming inhibitory signals into stimulatory signals for...

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Share to CD28 Antigens
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Gene Dosage

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Share to Lymphoma, T-Cell

Share to Oncogene Proteins, Fusion

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Source

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Identifiers

PMID: 26819049
DOI: 10.3324/haematol.2015.139253
PMCID: PMC5013939

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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