Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical significance of CD28 gene-related activating alterations in adult T-cell leukaemia/lymphoma.

British journal of haematology - 1 Jan 2021

Sakamoto Yuma, Ishida Takashi, Masaki Ayako, Takeshita Morishige, Iwasaki Hiromi, Yonekura Kentaro, Tashiro Yukie, Ito Asahi, Kusumoto Shigeru, Utsunomiya Atae, Iida Shinsuke, Ueda Ryuzo, Inagaki Hiroshi

Abstract excerpt

Multiple oncogenic events are involved in the development of adult T-cell leukaemia/lymphoma (ATL). Because CD28 plays a pivotal role in T-cell activation, we focused on alterations of the CD28 gene in ATL. We found multiple genetic abnormalities related to CD28 among the 144 patients enrolled in the present study. These involved gene fusions with the cytotoxic T-lymphocyte-associated antigen 4 or the inducible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD28 Antigens

Share to DNA Copy Number Variations

Share to Hematopoietic Stem Cell Transplantation

Share to Leukemia-Lymphoma, Adult T-Cell

Share to Mutation

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33205842
DOI: 10.1111/bjh.17211
PMCID: PMC7894310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical significance of CD28 gene-related activating alterations in adult T-cell leukaemia/lymphoma.PMID 33205842Read ↗

Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.Semantic proximity Read ↗

Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma.Semantic proximity Read ↗

Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.Semantic proximity Read ↗

A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patientsSemantic proximity Read ↗

Considering B7-CD28 as a family through sequence and structureSemantic proximity Read ↗

Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma.Semantic proximity Read ↗

The Role of the CD28 Family Receptors in T-Cell ImmunomodulationSemantic proximity Read ↗

Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency.Semantic proximity Read ↗

Genetic Variation of Costimulatory Molecules, Including Cytotoxic T-Lymphocyte Antigen 4, Inducible T-Cell Costimulator, Cluster Differentiation 28, and Programmed Cell Death 1 Genes, in Iranian Patients With Leukemia.Semantic proximity Read ↗

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activationSemantic proximity Read ↗

Costimulatory connections: CARMIL2 and CD28.Semantic proximity Read ↗

DUSP22-rearranged primary cutaneous CD30-positive T-cell lymphoproliferative disorders and adult T-cell leukemia/lymphoma frequently share the LEF1+/TIA1- immunophenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.