Article
Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma.
American journal of hematology - 1 Sept 2025
Bouska Alyssa, Zhang Weiwei, Sharma Sunandini, Holte Harald, Shah Rauf A, Lone Waseem G, Soma Mahfuza Afroz, Yang Ruimeng, Liu Xuxiang, Mehmood Syed, Chawla Ravneet Singh, Cappelli Luca Vincenzo, Fiore Danilo, Gong Qiang, Heavican-Foral Tayla B, Cannatella Jeffrey J, Amador Catalina, Arif Aiza, Smith Lynette M, Lim Soon Thye, Ong Choon Kiat, Feldman Andrew L, Du Ming-Qing, Perry Anamarija M, de Leval Laurence, Greiner Timothy C, Fu Kai, Trøen Gunhild, Vodák Daniel, Nakken Sigve, Delabie Jan, Weinstock David, Pileri Stefano, Laginestra Antonella, Kim KyeongJin, Pajvani Utpal, Vose Julie M, Weisenburger Dennis D, Horwitz Steven M, Dave Sandeep, Khoury Joseph, Inghirami Giorgio, Chan Wing C, Iqbal Javeed
Abstract excerpt
Nodal follicular helper T-cell (T FH) lymphoma of the angioimmunoblastic (AITL) subtype has a dismal prognosis. Using whole-exome sequencing (n = 124), transcriptomic (n = 78), and methylation (n = 40) analysis, we identified recurrent mutations in known epigenetic drivers (TET2, DNMT3A, IDH2 R172 ) and novel ones (TET3, KMT2D). TET2, IDH2 R172 , DNMT3A co-mutated AITLs had poor prognosis (p < 0.0001). Genes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.