Advances in the pathogenesis and therapeutic strategies of angioimmunoblastic T-cell lymphoma.

doi:10.1007/s10238-023-01197-9

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Article

Advances in the pathogenesis and therapeutic strategies of angioimmunoblastic T-cell lymphoma.

Clinical and experimental medicine - 1 Dec 2023

Zhang Qingyang, Yin Le, Lai Qinqiao, Zhao Yan, Peng Hongling

Abstract excerpt

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphomas with its cell origin determined to be follicular helper T-cells. AITL is characterized by a prominent tumor microenvironment involving dysregulation of immune cells, signaling pathways, and extracellular matrix. Significant progress has been made in the molecular pathophysiology of AITL, including genetic mutations,...

Topics

Humans
Immunoblastic Lymphadenopathy
Lymphoma, T-Cell, Peripheral
Mutation
Signal Transduction
Tumor Microenvironment

Source

Open in PubMed

Identifiers

PMID: 37759042
DOI: 10.1007/s10238-023-01197-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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