Article
Advances in the pathogenesis and therapeutic strategies of angioimmunoblastic T-cell lymphoma.
Clinical and experimental medicine - 1 Dec 2023
Zhang Qingyang, Yin Le, Lai Qinqiao, Zhao Yan, Peng Hongling
Abstract excerpt
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphomas with its cell origin determined to be follicular helper T-cells. AITL is characterized by a prominent tumor microenvironment involving dysregulation of immune cells, signaling pathways, and extracellular matrix. Significant progress has been made in the molecular pathophysiology of AITL, including genetic mutations,...
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