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Article

Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.

Leukemia - 1 May 2016

Rohr J, Guo S, Huo J, Bouska A, Lachel C, Li Y, Simone P D, Zhang W, Gong Q, Wang C, Cannon A, Heavican T, Mottok A, Hung S, Rosenwald A, Gascoyne R, Fu K, Greiner T C, Weisenburger D D, Vose J M, Staudt L M, Xiao W, Borgstahl G E O, Davis S, Steidl C, McKeithan T, Iqbal J, Chan W C

Abstract excerpt

Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-cell neoplasms with a poor prognosis. Recently, mutations in TET2 and other epigenetic modifiers as well as RHOA have been identified in these diseases, particularly in angioimmunoblastic T-cell lymphoma (AITL). CD28 is the major co-stimulatory receptor in T cells which, upon binding ligand, induces sustained T-cell proliferation and...

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Topics

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Share to NF-kappa B
Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to B7-2 Antigen

Share to CD28 Antigens

Share to Gene Expression Regulation, Neoplastic

Share to Lymphoma, T-Cell, Peripheral

Share to Surface Plasmon Resonance

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 26719098
DOI: 10.1038/leu.2015.357
PMCID: PMC5688878

Genes

GRAP2
GRB2
RHOA
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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