Article
Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.
Blood - 23 Apr 2020
Yoshida Noriaki, Shigemori Kay, Donaldson Nicholas, Trevisani Christopher, Cordero Nicolas A, Stevenson Kristen E, Bu Xia, Arakawa Fumiko, Takeuchi Mai, Ohshima Koichi, Yoda Akinori, Ng Samuel Y, Weinstock David M
Abstract excerpt
Adult T-cell leukemia/lymphoma (ATLL) in Japan presents at a median age of 70 years and only 5% of patients are <50 years of age. We conducted RNA and targeted DNA sequencing of 8 ATLLs from Japanese patients <50 years of age and identified 3 (37.5%) with both CTLA4-CD28 and inducible costimulator (ICOS)-CD28 fusions. Mutations of PLCG1, PRKCB, and STAT3, which were frequent in other ATLL-sequencing studies, were...
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