Article
A targeted mutational landscape of angioimmunoblastic T-cell lymphoma.
Blood - 27 Feb 2014
Odejide Oreofe, Weigert Oliver, Lane Andrew A, Toscano Dan, Lunning Matthew A, Kopp Nadja, Kim Sunhee, van Bodegom Diederik, Bolla Sudha, Schatz Jonathan H, Teruya-Feldstein Julie, Hochberg Ephraim, Louissaint Abner, Dorfman David, Stevenson Kristen, Rodig Scott J, Piccaluga Pier Paolo, Jacobsen Eric, Pileri Stefano A, Harris Nancy L, Ferrero Simone, Inghirami Giorgio, Horwitz Steven M, Weinstock David M
Abstract excerpt
The genetics of angioimmunoblastic T-cell lymphoma (AITL) are very poorly understood. We defined the mutational landscape of AITL across 219 genes in 85 cases from the United States and Europe. We identified ≥2 mutations in 34 genes, nearly all of which were not previously implicated in AITL. These included loss-of-function mutations in TP53 (n = 4), ETV6 (n = 3), CCND3 (n = 2), and EP300 (n = 5), as well as...
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