Article
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.
Cancer cell - 13 Feb 2023
Leca Julie, Lemonnier Franҫois, Meydan Cem, Foox Jonathan, El Ghamrasni Samah, Mboumba Diana-Laure, Duncan Gordon S, Fortin Jerome, Sakamoto Takashi, Tobin Chantal, Hodgson Kelsey, Haight Jillian, Smith Logan K, Elia Andrew J, Butler Daniel, Berger Thorsten, de Leval Laurence, Mason Christopher E, Melnick Ari, Gaulard Philippe, Mak Tak W
Abstract excerpt
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME). IDH2 and TET2 mutations co-occur frequently in AITL, but their contribution to tumorigenesis is poorly understood. We developed an AITL mouse model that is driven by Idh2 and Tet2 mutations. Malignant Tfh cells display aberrant...
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