Angioimmunoblastic T-cell lymphoma contains multiple clonal T-cell populations derived from a common TET2 mutant progenitor cell.

doi:10.1002/path.5376

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Article

Angioimmunoblastic T-cell lymphoma contains multiple clonal T-cell populations derived from a common TET2 mutant progenitor cell.

The Journal of pathology - 1 Mar 2020

Yao Wen-Qing, Wu Fangtian, Zhang Wenyan, Chuang Shih-Sung, Thompson Joe S, Chen Zi, Zhang Shao-Wei, Clipson Alexandra, Wang Ming, Liu Hongxiang, Bibawi Hani, Huang Yuanxue, Campos Luis, Grant John W, Wright Penny, Ei-Daly Hesham, Rásó-Barnett Lívia, Farkas Lorant, Follows George A, Gao Zifen, Attygalle Ayoma D, Ashton-Key Margaret, Liu Weiping, Du Ming-Qing

Abstract excerpt

Angioimmunoblastic T-cell lymphoma (AITL) is a neoplastic proliferation of T follicular helper cells with clinical and histological presentations suggesting a role of antigenic drive in its development. Genetically, it is characterized by a stepwise acquisition of somatic mutations, with early mutations involving epigenetic regulators (TET2, DNMT3A) and occurring in haematopoietic stem cells, with subsequent...

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PMID: 31859368
DOI: 10.1002/path.5376
PMCID: PMC7064999

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