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Article

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease.

Journal of neuroinflammation - 27 Jan 2016

Couturier Julien, Stancu Ilie-Cosmin, Schakman Olivier, Pierrot Nathalie, Huaux François, Kienlen-Campard Pascal, Dewachter Ilse, Octave Jean-Noël

Abstract excerpt

BACKGROUND: The proinflammatory cytokine interleukin-1β (IL-1β) is overexpressed in Alzheimer disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide triggers activation of inflammasomes, protein complexes responsible for IL-1β maturation in microglial cells. Downregulation of NALP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome has been shown to decrease amyloid load and...

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Identifiers

PMID: 26818951
DOI: 10.1186/s12974-016-0477-y
PMCID: PMC4729126

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CCL3

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