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Article

NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model.

Inflammation - 1 Feb 2018

Gugliandolo Agnese, Giacoppo Sabrina, Bramanti Placido, Mazzon Emanuela

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a disabling progressive disease characterized by the degeneration of motor neurons, leading to muscle atrophy and paralysis. The majority of cases are sporadic, but also a familiar form of ALS exists, and some genes causative of the pathology were found. In particular, mutations in superoxide dismutase 1 (SOD1) were found in 20% of familiar cases. It is known that...

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Source

Identifiers

PMID: 28936769
DOI: 10.1007/s10753-017-0667-5

Genes

NLRP3
SOD1
TLR4

Provenance

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