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Article

Critical role for the AIM2 inflammasome during acute CNS bacterial infection.

Journal of neurochemistry - 1 May 2014

Hanamsagar Richa, Aldrich Amy, Kielian Tammy

Abstract excerpt

Interleukin-1β (IL-1β) is essential for eliciting protective immunity during the acute phase of Staphylococcus aureus (S. aureus) infection in the central nervous system (CNS). We previously demonstrated that microglial IL-1β production in response to live S. aureus is mediated through the Nod-like receptor protein 3 (NLRP3) inflammasome, including the adapter protein ASC (apoptosis-associated speck-like protein...

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Topics

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Share to CARD Signaling Adaptor Proteins
Share to Caspase 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24484406
DOI: 10.1111/jnc.12669
PMCID: PMC3999210

Genes

AIM2
NLRP3
CCL2
CXCL1
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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