Article

The loss of enzymatic activity of the PHARC associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammation

2021-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Phagocytosis is an important evolutionary conserved process, essential for clearing pathogens and cellular debris in higher organisms, including humans. This well-orchestrated innate immunological response is intricately regulated by numerous cellular factors, important amongst which, are the immunomodulatory lysophosphatidylserines (lyso-PSs) and the pro-apoptotic oxidized phosphatidylserines (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbcc7018-c548-5315-b1af-2e010c88c91b
DOI: 10.1101/2021.08.22.457059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The loss of enzymatic activity of the PHARC associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammationDOI 10.1101/2021.08.22.457059Read

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC.Semantic proximity Read

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.Semantic proximity Read

Phagocytic activity of perivascular cell promotes CNS injury pathologySemantic proximity Read

Eat‐me signals: Keys to molecular phagocyte biology and “Appetite” controlSemantic proximity Read

Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nervesSemantic proximity Read

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosisSemantic proximity Read

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer’s Disease Revealed by Pharmacological and Genetic Microglial DepletionSemantic proximity Read

Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease.Semantic proximity Read

Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.Semantic proximity Read

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microgliaSemantic proximity Read

Neuroinflammation in an optimized model of lysophosphatidic acid (LPA)-induced post-hemorrhagic hydrocephalusSemantic proximity Read

TREM2 knockout, but not the R47H Alzheimer’s variant, reduces neural phagocytosis and survival of human iPSC-derived macrophagesSemantic proximity Read