Article
Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS.
PLoS genetics - 1 Jan 2016
Wang Yunpeng, Thompson Wesley K, Schork Andrew J, Holland Dominic, Chen Chi-Hua, Bettella Francesco, Desikan Rahul S, Li Wen, Witoelar Aree, Zuber Verena, Devor Anna, Nöthen Markus M, Rietschel Marcella, Chen Qiang, Werge Thomas, Cichon Sven, Weinberger Daniel R, Djurovic Srdjan, O'Donovan Michael, Visscher Peter M, Andreassen Ole A, Dale Anders M
Abstract excerpt
Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy) for each single nucleotide polymorphism (SNP) to enable more accurate estimation of replication probabilities,...
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