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Article

Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data.

Translational psychiatry - 18 Dec 2017

Polushina Tatiana, Giddaluru Sudheer, Bettella Francesco, Espeseth Thomas, Lundervold Astri J, Djurovic Srdjan, Cichon Sven, Hoffmann Per, Nöthen Markus M, Steen Vidar M, Andreassen Ole A, Le Hellard Stéphanie

Abstract excerpt

We have tested published methods for capturing allelic heterogeneity and identifying loci of joint effects to uncover more of the "hidden heritability" of schizophrenia (SCZ). We used two tools, cojo-GCTA and multi-SNP, to analyze meta-statistics from the latest genome-wide association study (GWAS) on SCZ by the Psychiatric Genomics Consortium (PGC). Stepwise regression on markers with p values <10-7 in cojo-GCTA...

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Identifiers

PMID: 29249828
DOI: 10.1038/s41398-017-0033-2
PMCID: PMC5802566

Genes

PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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