Article
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.
American journal of human genetics - 7 Feb 2013
Andreassen Ole A, Djurovic Srdjan, Thompson Wesley K, Schork Andrew J, Kendler Kenneth S, O'Donovan Michael C, Rujescu Dan, Werge Thomas, van de Bunt Martijn, Morris Andrew P, McCarthy Mark I, Roddey J Cooper, McEvoy Linda K, Desikan Rahul S, Dale Anders M
Abstract excerpt
Several lines of evidence suggest that genome-wide association studies (GWASs) have the potential to explain more of the "missing heritability" of common complex phenotypes. However, reliable methods for identifying a larger proportion of SNPs are currently lacking. Here, we present a genetic-pleiotropy-informed method for improving gene discovery with the use of GWAS summary-statistics data. We applied this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.