Article

Improved functional mapping with GSA-MiXeR implicates biologically specific gene-sets and estimates enrichment magnitude

2022-12-13

Abstract excerpt

While genome-wide association studies (GWAS) are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging. We developed the GSA-MiXeR analytical tool for gene-set analysis (GSA), which fits a model for gene-set heritability enrichments for complex traits, accounting for linkage disequilibrium across v...

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Literature Corpus work: 5e1578fa-baf0-562a-8279-c4853bdcf370
DOI: 10.1101/2022.12.08.22283159

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