Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2016

Hayashi Masahiro, Jin Ying, Yorgov Daniel, Santorico Stephanie A, Hagman James, Ferrara Tracey M, Jones Kenneth L, Cavalli Giulio, Dinarello Charles A, Spritz Richard A

Abstract excerpt

HLA-A is a class I major histocompatibility complex receptor that presents peptide antigens on the surface of most cells. Vitiligo, an autoimmune disease in which skin melanocytes are destroyed by cognate T cells, is associated with variation in the HLA-A gene; specifically HLA-A*02:01, which presents multiple vitiligo melanocyte autoantigens. Refined genetic mapping localizes vitiligo risk in the HLA-A region to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haplotypes

Share to HLA-A Antigens

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Transcription, Genetic

Share to Vitiligo

Source

Open in PubMed Open full text

Identifiers

PMID: 26787886
DOI: 10.1073/pnas.1525001113
PMCID: PMC4747738

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo.PMID 26787886Read ↗

MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.Semantic proximity Read ↗

Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.Semantic proximity Read ↗

The HLA genomic loci map: expression, interaction, diversity and disease.Semantic proximity Read ↗

Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits.Semantic proximity Read ↗

An active chromatin interactome in relevant cell lines elucidates biological mechanisms at genetic risk loci for dermatological traitsSemantic proximity Read ↗

Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cellsSemantic proximity Read ↗

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci.Semantic proximity Read ↗

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunitySemantic proximity Read ↗

Interactome analysis of gene expression profile reveals potential novel key transcriptional regulators of skin pathology in vitiligo.Semantic proximity Read ↗

Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31.Semantic proximity Read ↗

Expression of classical HLA class I molecules: regulation and clinical impacts: Julia Bodmer Award Review 2015.Semantic proximity Read ↗

Tissue-specific Gene Expression Prediction Associates Vitiligo with SUOX through an Active EnhancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.