Article
Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.
Nature genetics - 1 Nov 2016
Jin Ying, Andersen Genevieve, Yorgov Daniel, Ferrara Tracey M, Ben Songtao, Brownson Kelly M, Holland Paulene J, Birlea Stanca A, Siebert Janet, Hartmann Anke, Lienert Anne, van Geel Nanja, Lambert Jo, Luiten Rosalie M, Wolkerstorfer Albert, Wietze van der Veen J P, Bennett Dorothy C, Taïeb Alain, Ezzedine Khaled, Kemp E Helen, Gawkrodger David J, Weetman Anthony P, Kõks Sulev, Prans Ele, Kingo Külli, Karelson Maire, Wallace Margaret R, McCormack Wayne T, Overbeck Andreas, Moretti Silvia, Colucci Roberta, Picardo Mauro, Silverberg Nanette B, Olsson Mats, Valle Yan, Korobko Igor, Böhm Markus, Lim Henry W, Hamzavi Iltefat, Zhou Li, Mi Qing-Sheng, Fain Pamela R, Santorico Stephanie A, Spritz Richard A
Abstract excerpt
Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of melanocytes, with epidemiological association with other autoimmune diseases. In previous linkage and genome-wide association studies (GWAS1 and GWAS2), we identified 27 vitiligo susceptibility loci in patients of European ancestry. We carried out a third GWAS (GWAS3) in European-ancestry subjects, with augmented GWAS1 and...
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