Article
MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2016
Cavalli Giulio, Hayashi Masahiro, Jin Ying, Yorgov Daniel, Santorico Stephanie A, Holcomb Cherie, Rastrou Melinda, Erlich Henry, Tengesdal Isak W, Dagna Lorenzo, Neff C Preston, Palmer Brent E, Spritz Richard A, Dinarello Charles A
Abstract excerpt
Genetic risk for autoimmunity in HLA genes is most often attributed to structural specificity resulting in presentation of self-antigens. Autoimmune vitiligo is strongly associated with the MHC class II region. Here, we fine-map vitiligo MHC class II genetic risk to three SNPs only 47 bp apart, located within a predicted super-enhancer in an intergenic region between HLA-DRB1 and HLA-DQA1, localized by a...
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