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Article

Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics

18 Apr 2015

Abstract excerpt

Aberrations in the cyclin-dependent kinase (CDK) pathways that regulate the cell cycle restriction point contribute to genomic instability and tumor proliferation, and can be targeted by recently developed CDK inhibitors. We therefore investigated the clinical correlates of CDK4/6 and CDKN2A/B abnormalities in diverse malignancies. Patients with various cancers who underwent molecular profiling by targeted next...

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PMID: 25695927
DOI: 10.1080/15384101.2015.1014149

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