Article
Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment.
Cell reports - 14 Jul 2020
Shan Weiwei, Yuan Jiao, Hu Zhongyi, Jiang Junjie, Wang Yueying, Loo Nicki, Fan Lingling, Tang Zhaoqing, Zhang Tianli, Xu Mu, Pan Yutian, Lu Jiaqi, Long Meixiao, Tanyi Janos L, Montone Kathleen T, Fan Yi, Hu Xiaowen, Zhang Youyou, Zhang Lin
Abstract excerpt
Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations. In contrast to cell-cycle-related CDKs/cyclins, which are globally amplified, transcriptional CDKs/cyclins recurrently lose copy numbers across cancers. Although mutations and transcript...
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