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Article

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.

Nucleic acids research - 11 Mar 2015

Ekumi Kingsley M, Paculova Hana, Lenasi Tina, Pospichalova Vendula, Bösken Christian A, Rybarikova Jana, Bryja Vitezslav, Geyer Matthias, Blazek Dalibor, Barboric Matjaz

Abstract excerpt

The Cdk12/CycK complex promotes expression of a subset of RNA polymerase II genes, including those of the DNA damage response. CDK12 is among only nine genes with recurrent somatic mutations in high-grade serous ovarian carcinoma. However, the influence of these mutations on the Cdk12/CycK complex and their link to cancerogenesis remain ill-defined. Here, we show that most mutations prevent formation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25712099
DOI: 10.1093/nar/gkv101
PMCID: PMC4357706

Genes

CDK12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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