Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased Olfactory Bulb BDNF Expression Does Not Rescue Deficits in Olfactory Neurogenesis in the Huntington's Disease R6/2 Mouse.

Chemical senses - 1 Mar 2016

Smail Shamayra, Bahga Dalbir, McDole Brittnee, Guthrie Kathleen

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by expansion of CAG trinucleotide repeats in the huntingtin gene. Mutant huntingtin protein (mhtt) interferes with the actions of brain-derived neurotrophic factor (BDNF), and BDNF signaling is reduced in the diseased striatum. Loss of this trophic support is thought to contribute to loss of striatal medium spiny neurons in HD. Increasing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Neurogenesis

Share to Olfactory Bulb

Share to Serotonin Plasma Membrane Transport Proteins

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 26783111
DOI: 10.1093/chemse/bjv076
PMCID: PMC4834850

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased Olfactory Bulb BDNF Expression Does Not Rescue Deficits in Olfactory Neurogenesis in the Huntington's Disease R6/2 Mouse.PMID 26783111Read ↗

Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease miceSemantic proximity Read ↗

Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus.Semantic proximity Read ↗

Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.Semantic proximity Read ↗

Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes in R6/2 miceSemantic proximity Read ↗

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.Semantic proximity Read ↗

Stability of dentate gyrus granule cell mossy fiber BDNF protein expression with age and resistance of granule cells to Alzheimer’s disease neuropathology in a mouse modelSemantic proximity Read ↗

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons.Semantic proximity Read ↗

Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.Semantic proximity Read ↗

Striatal infusion of glial conditioned medium diminishes huntingtin pathology in r6/1 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.