Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.

Journal of neurochemistry - 1 Apr 2008

Gharami Kusumika, Xie Yuxiang, An Juan Ji, Tonegawa Susumu, Xu Baoji

Abstract excerpt

Huntington's disease (HD), a dominantly inherited neurodegenerative disorder characterized by relatively selective degeneration of striatal neurons, is caused by an expanded polyglutamine tract of the huntingtin (htt) protein. The htt mutation reduces levels of brain-derived neurotrophic factor (BDNF) in the striatum, likely by inhibiting cortical BDNF gene expression and anterograde transport of BDNF from cortex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Dopamine and cAMP-Regulated Phosphoprotein 32

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enkephalins

Share to Huntingtin Protein

Share to Huntington Disease

Share to Nerve Tissue Proteins

Share to Nuclear Proteins

Share to Prosencephalon

Source

Open in PubMed Open full text

Identifiers

PMID: 18086127
DOI: 10.1111/j.1471-4159.2007.05137.x
PMCID: PMC2377033

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.PMID 18086127Read ↗

BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice.Semantic proximity Read ↗

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.Semantic proximity Read ↗

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brainSemantic proximity Read ↗

Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Huntington's disease.Semantic proximity Read ↗

Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.Semantic proximity Read ↗

The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.Semantic proximity Read ↗

Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice.Semantic proximity Read ↗

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice.Semantic proximity Read ↗

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.Semantic proximity Read ↗

RESEARCH ARTICLE: Systematic Assessment of BDNF and Its Receptor Levels in Human Cortices Affected by Huntington's DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.