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Article

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons.

Neuroscience - 5 Jan 2007

Harburg G C, Hall F S, Harrist A V, Sora I, Uhl G R, Eisch A J

Abstract excerpt

Recent evidence suggests that mu opioid receptors (MOR) are key regulators of hippocampal structure and function. For example, exogenous MOR agonists morphine and heroin negatively impact hippocampal function and decrease adult hippocampal neurogenesis. Here we explored the role of MOR in the birth and survival of hippocampal progenitor cells by examining adult neurogenesis in mice that lack MOR. Adult male mice...

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Identifiers

PMID: 17055658
DOI: 10.1016/j.neuroscience.2006.09.018
PMCID: PMC2230097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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