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Article

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.

Journal of neurochemistry - 1 Jun 2005

Pineda José R, Canals Josep M, Bosch Miquel, Adell Albert, Mengod Guadalupe, Artigas Francesc, Ernfors Patrik, Alberch Jordi

Abstract excerpt

Dysfunction of dopaminergic neurons may contribute to motor impairment in Huntington's disease. Here, we study the role of brain-derived neurotrophic factor (BDNF) in alterations of the nigrostriatal system associated with transgenics carrying mutant huntingtin. Using huntingtin-BDNF+/- double-mu...

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Source

Identifiers

PMID: 15934928
DOI: 10.1111/j.1471-4159.2005.03047.x

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15934928-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.PMID 15934928Read ↗

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The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.Semantic proximity Read ↗

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In vivo Dopamine Efflux is Decreased in Striatum of both Fragment (R6/2) and Full-Length (YAC128) Transgenic Mouse Models of Huntington's DiseaseSemantic proximity Read ↗

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