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Article

Striatal infusion of glial conditioned medium diminishes huntingtin pathology in r6/1 mice.

PloS one - 1 Jan 2013

Perucho Juan, Casarejos Maria José, Gómez Ana, Ruíz Carolina, Fernández-Estevez Maria Ángeles, Muñoz Maria Paz, de Yébenes Justo García, Mena Maria Ángeles

Abstract excerpt

Huntington's disease is a neurodegenerative disorder caused by an expansion of CAG repeats in the huntingtin gene which produces widespread neuronal and glial pathology. We here investigated the possible therapeutic role of glia or glial products in Huntington's disease using striatal glial conditioned medium (GCM) from fetus mice (E16) continuously infused for 15 and 30 days with osmotic minipumps into the left...

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Identifiers

PMID: 24069174
DOI: 10.1371/journal.pone.0073120
PMCID: PMC3771920

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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