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Article

Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.

Neurobiology of aging - 1 Jun 2008

Winner Beate, Rockenstein Edward, Lie D Chichung, Aigner Robert, Mante Michael, Bogdahn Ulrich, Couillard-Despres Sebastien, Masliah Eliezer, Winkler Jürgen

Abstract excerpt

In Parkinson disease, wild-type alpha-synuclein accumulates during aging, whereas alpha-synuclein mutations lead to an early onset and accelerated course of the disease. The generation of new neurons is decreased in regions of neurogenesis in adult mice overexpressing wild-type human alpha-synuclein. We examined the subventricular zone/olfactory bulb neurogenesis in aged mice expressing either wild-type human or...

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Identifiers

PMID: 17275140
DOI: 10.1016/j.neurobiolaging.2006.12.016
PMCID: PMC2896275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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