Article

Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes in R6/2 mice

2024-05-01

Abstract excerpt

<h4>Summary</h4> Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder characterized by striatal atrophy. Reduced trophic support due to decreased striatal levels of neurotrophins (NTs), mainly brain-derived neurotrophic factor (BDNF), contributes importantly to HD pathogenesis; restoring NTs has significant therapeutic potential. Human pluripotent stem cells (hPSC) offer a scalable platfo...

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Literature Corpus work: edbdaa23-4b7a-58c9-bd08-c268f87943db
DOI: 10.1101/2024.05.01.592095

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