Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.

Genes, brain, and behavior - 1 Feb 2013

Samadi P, Boutet A, Rymar V V, Rawal K, Maheux J, Kvann J-C, Tomaszewski M, Beaubien F, Cloutier J F, Levesque D, Sadikot A F

Abstract excerpt

Patients with Huntington's disease (HD) and transgenic mouse models of HD show neuronal loss in the striatum as a major feature, which contributes to cognitive and motor manifestations. Reduced expression of the neurotrophin brain-derived neurotrophic factor (BDNF) in striatal afferents may play a role in neuronal loss. How progressive loss of BDNF expression in different cortical or subcortical afferents...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Afferent Pathways
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Hand Strength

Share to Huntington Disease

Share to Mice, Inbred CBA

Share to Neostriatum

Share to Thalamus

Source

Identifiers

PMID: 23006318
DOI: 10.1111/j.1601-183X.2012.00858.x

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.PMID 23006318Read ↗

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.Semantic proximity Read ↗

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic miceSemantic proximity Read ↗

RESEARCH ARTICLE: Systematic Assessment of BDNF and Its Receptor Levels in Human Cortices Affected by Huntington's DiseaseSemantic proximity Read ↗

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.Semantic proximity Read ↗

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease miceSemantic proximity Read ↗

BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice.Semantic proximity Read ↗

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brainSemantic proximity Read ↗

Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/2 mouse model of HD.Semantic proximity Read ↗

Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.Semantic proximity Read ↗

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6. <i>Htt</i> <sup> <i>Q111/+</i> </sup> model of Huntington’s diseaseSemantic proximity Read ↗

Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.