Article
PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth.
Annals of the rheumatic diseases - 1 Dec 2016
Kc Ranjan, Li Xin, Kroin Jeffrey S, Liu Zhiqiang, Chen Di, Xiao Guozhi, Levine Brett, Li Jinyuan, Hamilton John L, van Wijnen Andre J, Piel Margaret, Shelly Daniel A, Brass Dovrat, Kolb Ela, Im Hee-Jeong
Abstract excerpt
OBJECTIVES: A key clinical paradox in osteoarthritis (OA), a prevalent age-related joint disorder characterised by cartilage degeneration and debilitating pain, is that the severity of joint pain does not strictly correlate with radiographic and histological defects in joint tissues. Here, we determined whether protein kinase Cδ (PKCδ), a key mediator of cartilage degeneration, is critical to the mechanism by...
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