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Article

Refining surgical models of osteoarthritis in mice and rats alters pain phenotype but not joint pathology.

PloS one - 1 Jan 2020

Gowler Peter R W, Mapp Paul I, Burston James J, Shahtaheri Mohsen, Walsh David A, Chapman Victoria

Abstract excerpt

The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining surgical small rodent models of OA on both joint pathology and pain behaviour. Adult male C57BL/6 mice (n = 76, 10-11 weeks of age at time of surgery) underwent either...

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Identifiers

PMID: 32991618
DOI: 10.1371/journal.pone.0239663
PMCID: PMC7523978

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