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Article

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis.

Arthritis and rheumatism - 1 Feb 2012

Kozawa Eiji, Nishida Yoshihiro, Cheng Xian Wu, Urakawa Hiroshi, Arai Eisuke, Futamura Naohisa, Shi Guo-Ping, Kuzuya Masafumi, Hu Lina, Sasaki Takeshi, Ishiguro Naoki

Abstract excerpt

OBJECTIVE: Several studies have shown that cathepsin K (CTK) is overexpressed in osteoarthritic (OA) cartilage and subchondral bone. However, it has not been well established whether CTK expression is harmful or beneficial. We undertook this study to investigate the direct involvement of CTK in OA development using Ctsk-knockout (Ctsk(-/-)) mice in a joint instability-induced model of OA. METHODS: We analyzed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21968827
DOI: 10.1002/art.33398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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