Article

NERVE GROWTH FACTOR IS SUFFICIENT TO CAUSE MULTIPLE OSTEOARTHRITIS-RELEVANT PATHOLOGICAL FEATURES IN NAÏVE MURINE KNEE JOINTS

2025-06-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Nerve growth factor (NGF), a key mediator of pain and inflammation, is increased in joints with osteoarthritis (OA). Neutralizing NGF with monoclonal antibodies has shown analgesic effects in painful knee OA, but clinical development was stopped due to side effects in the joints. Knowledge about the biological effects of long-term exposure of joint tissues to NGF is limited....

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Literature Corpus work: 551cb7d2-c718-5f36-8143-0505543ec09b
DOI: 10.1101/2025.06.20.660696

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