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Article

PKC Theta Ablation Improves Healing in a Mouse Model of Muscular Dystrophy

14 Feb 2012

Abstract excerpt

Inflammation is a key pathological characteristic of dystrophic muscle lesion formation, limiting muscle regeneration and resulting in fibrotic and fatty tissue replacement of muscle, which exacerbates the wasting process in dystrophic muscles. Limiting immune response is thus one of the therapeutic options to improve healing, as well as to improve the efficacy of gene- or cell-mediated strategies to restore...

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PMID: 22348094
DOI: 10.1371/journal.pone.0031515

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