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3D Light Sheet Microscopy Reveals Aging Osteoarthritis-associated Joint-innervated Nerve Remodeling in Mouse Knee Joints

2026-01-10

Abstract excerpt

<h4>Objectives</h4> Osteoarthritis (OA) is a prevalent age related joint disease-causing chronic pain. This study investigated how nociceptive and sympathetic nerve innervation in the mouse knee joint changes with age and OA progression, and how these changes relate to pain and disease severity. <h4>Methods</h4> Thirty-eight mice were assigned to four groups: young male (M y ), aged male (M a ), young female (...

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Literature Corpus work
e4c2a6f7-5a72-5603-8a22-3187915780a7
DOI
10.64898/2026.01.09.698640
Open publication

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3D Light Sheet Microscopy Reveals Aging Osteoarthritis-associated Joint-innervated Nerve Remodeling in Mouse Knee JointsDOI 10.64898/2026.01.09.698640
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