Article

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis

2022-03-13

Abstract excerpt

Osteoarthritis is a very common painful joint disease, for which few treatment options exist. New non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in development of mechanical pain, but the mechanisms by which this occurs remain poorly understood. We observed that in t...

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Literature Corpus work: 21a43ea0-2ab2-5288-94d4-b310cff1e51f
DOI: 10.1101/2022.03.12.484097

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