Article
Testing association and maternally mediated genetic effects with the principal component analysis in case-parents studies.
BMC genetics - 19 Jan 2016
Li Yumei, Xiang Yang
Abstract excerpt
BACKGROUND: Major advances in genotyping technology have generated high-density maps of single nucleotide polymorphism (SNP) markers that provide an unprecedented opportunity to identify genes underlying complex traits. Several family-based statistical methods showing robust population stratification have been developed to test the association between multiple markers and disease-susceptibility genes. Only a few...
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