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Article

Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models.

PLoS genetics - 1 May 2020

Bhatnagar Sahir R, Yang Yi, Lu Tianyuan, Schurr Erwin, Loredo-Osti J C, Forest Marie, Oualkacha Karim, Greenwood Celia M T

Abstract excerpt

Complex traits are known to be influenced by a combination of environmental factors and rare and common genetic variants. However, detection of such multivariate associations can be compromised by low statistical power and confounding by population structure. Linear mixed effects models (LMM) can account for correlations due to relatedness but have not been applicable in high-dimensional (HD) settings where the...

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PMID: 32365090
DOI: 10.1371/journal.pgen.1008766
PMCID: PMC7224575

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