A novel test for testing the optimally weighted combination of rare and common variants based on data of parents and affected children.

Abstract excerpt

With the development of sequencing technologies, the direct testing of rare variant associations has become possible. Many statistical methods for detecting associations between rare variants and complex diseases have recently been developed, most of which are population-based methods for unrelated individuals. A limitation of population-based methods is that spurious associations can occur when there is a...

Topics

• Child
• Computer Simulation
• Female
• Genetic Predisposition to Disease
• Genetic Variation
• Genetics, Population
• Genome, Human
• Humans
• Male
• Models, Genetic
• Parents