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Article

Quantifying direct genetic signal captured by principal component adjustment.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2026

Sotoudeh Ramina, Trejo Sam, Harpak Arbel, Conley Dalton

Abstract excerpt

Contemporary genomic studies of complex traits, such as genome-wide association studies and polygenic index (PGI) analyses, frequently include the principal components of the genotype matrix (PCs) among their adjustments for population stratification. In this paper, we explore the extent to which we may be discounting direct genetic effects by adjusting for PCs. Using family-based models that control for parental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42060716
DOI: 10.1073/pnas.2525790123
PMCID: PMC13142912

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PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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