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Article

Using principal components of genetic variation for robust and powerful detection of gene-gene interactions in case-control and case-only studies.

American journal of human genetics - 12 Mar 2010

Bhattacharjee Samsiddhi, Wang Zhaoming, Ciampa Julia, Kraft Peter, Chanock Stephen, Yu Kai, Chatterjee Nilanjan

Abstract excerpt

Many popular methods for exploring gene-gene interactions, including the case-only approach, rely on the key assumption that physically distant loci are in linkage equilibrium in the underlying population. These methods utilize the presence of correlation between unlinked loci in a disease-enriched sample as evidence of interactions among the loci in the etiology of the disease. We use data from the CGEMS...

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Identifiers

PMID: 20206333
DOI: 10.1016/j.ajhg.2010.01.026
PMCID: PMC2833365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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