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Article

Variance component model to account for sample structure in genome-wide association studies.

Nature genetics - 1 Apr 2010

Kang Hyun Min, Sul Jae Hoon, Service Susan K, Zaitlen Noah A, Kong Sit-Yee, Freimer Nelson B, Sabatti Chiara, Eskin Eleazar

Abstract excerpt

Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious associations. Variance component approaches, such as efficient mixed-model association (EMMA), can correct for a wide range of sample structures by explicitly...

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Identifiers

PMID: 20208533
DOI: 10.1038/ng.548
PMCID: PMC3092069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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