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Article

Testing gene-gene interactions in the case-parents design.

Human heredity - 1 Jan 2011

Yu Zhaoxia

Abstract excerpt

The case-parents design has been widely used to detect genetic associations as it can prevent spurious association that could occur in population-based designs. When examining the effect of an individual genetic locus on a disease, logistic regressions developed by conditioning on parental genotypes provide complete protection from spurious association caused by population stratification. However, when testing...

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PMID: 21778736
DOI: 10.1159/000327355
PMCID: PMC3153343

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